MTD studies for the Marine Fungi Consortium

European ScreeningPort GmbH

A group of eleven institutions from 7 different countries has jointly set up a consortium of experts to cooperatively conduct the project 'MARINE FUNGI', which received funding from the European Commission under the 'Seventh Framework Programme' (FP7). The project is coordinated by the 'Helmholtz Zentrum für Ozeanforschung (GEOMAR)' Kiel, Germany.
The aim of MARINE FUNGI is to demonstrate the sustainable exploitation of under-utilised marine natural resources, namely fungi isolated from various marine sources. As well as demonstrating the efficient and scalable production of marine natural products, the project has been exploring marine fungi as a source of useful new natural compounds, with a therapeutic focus on the development of novel anti-cancer compounds. The scope of the project includes the characterization of the most promising compounds to the stage of in vivo proof of concept of anti-tumour efficacy.
Compounds with desirable characteristics and confirmed dose dependent in vitro biological activity in the context of the NCI60 collection of cancer cell lines1, will be subject to increasingly detailed assessment in higher content/value assays. The best compounds will be selected on the basis of in vitro compound efficacy performance, appropriate pharmaceutical potential and in vivo pharmacokinetic (PK) profiles. Following in vivo PK studies, up to 5 promising compounds will be subjected to a maximum tolerable dose assessment.
The objective is to define and document the requirements for the determination of the Maximal Tolerable Dose (MTD) of up to 5 compounds for the MARINE FUNGI Consortium.

Deadline

Die Frist für den Eingang der Angebote war 2013-12-06. Die Ausschreibung wurde veröffentlicht am 2013-11-27.

Wer? Wie? Wo?
Geschichte der Beschaffung
Datum Dokument
2013-11-27 Auftragsbekanntmachung
Auftragsbekanntmachung (2013-11-27)
Objekt
Umfang der Beschaffung
Titel: Dienstleistungen im Bereich Forschung und experimentelle Entwicklung
Menge oder Umfang:
Maximal Tolerable Dose (MTD) studies of up to 5 compounds for the MARINE FUNGI Consortium.5 00050 000
Metadaten der Bekanntmachung
Originalsprache: Englisch 🗣️
Dokumenttyp: Auftragsbekanntmachung
Art des Auftrags: Dienstleistungen
Verordnung: Europäische Union
Gemeinsames Vokabular für öffentliche Aufträge (CPV)
Code: Dienstleistungen im Bereich Forschung und experimentelle Entwicklung 📦

Verfahren
Verfahrensart: Offenes Verfahren
Angebotsart: Angebot für alle Lose
Vergabekriterien
Wirtschaftlichstes Angebot

Öffentlicher Auftraggeber
Identität
Land: Deutschland 🇩🇪
Art des öffentlichen Auftraggebers: Sonstiges
Name des öffentlichen Auftraggebers: European ScreeningPort GmbH
Postanschrift: Schnackenburgallee 114
Postleitzahl: 22525
Postort: Hamburg
Kontakt
Internetadresse: http://www.screeningport.com 🌏
E-Mail: tender@screeningport.com 📧
Telefon: +49 403037640 📞
Fax: +49 40303764100 📠

Referenz
Daten
Absendedatum: 2013-11-27 📅
Einreichungsfrist: 2013-12-06 📅
Veröffentlichungsdatum: 2013-11-29 📅
Kennungen
Bekanntmachungsnummer: 2013/S 232-403021
ABl. S-Ausgabe: 232

Objekt
Umfang der Beschaffung
Geschätzter Wert ohne MwSt: 5 000 💰
50 000 💰
Häufigkeit der zu vergebenden Aufträge: 2
Kurze Beschreibung:
A group of eleven institutions from 7 different countries has jointly set up a consortium of experts to cooperatively conduct the project 'MARINE FUNGI', which received funding from the European Commission under the 'Seventh Framework Programme' (FP7). The project is coordinated by the 'Helmholtz Zentrum für Ozeanforschung (GEOMAR)' Kiel, Germany.
Mehr anzeigen
The aim of MARINE FUNGI is to demonstrate the sustainable exploitation of under-utilised marine natural resources, namely fungi isolated from various marine sources. As well as demonstrating the efficient and scalable production of marine natural products, the project has been exploring marine fungi as a source of useful new natural compounds, with a therapeutic focus on the development of novel anti-cancer compounds. The scope of the project includes the characterization of the most promising compounds to the stage of in vivo proof of concept of anti-tumour efficacy.
Mehr anzeigen
Compounds with desirable characteristics and confirmed dose dependent in vitro biological activity in the context of the NCI60 collection of cancer cell lines1, will be subject to increasingly detailed assessment in higher content/value assays. The best compounds will be selected on the basis of in vitro compound efficacy performance, appropriate pharmaceutical potential and in vivo pharmacokinetic (PK) profiles. Following in vivo PK studies, up to 5 promising compounds will be subjected to a maximum tolerable dose assessment.
Mehr anzeigen
The objective is to define and document the requirements for the determination of the Maximal Tolerable Dose (MTD) of up to 5 compounds for the MARINE FUNGI Consortium.
Losnummer: 1
Bezeichnung des Loses: MTD studies for the Marine Fungi Consortium - compound 1
Zusätzliche Angaben zu den Losen:
The orders for each of the 5 MTD studies (Lots) will be placed individually by a specific partner of the MARINE FUNGI consortium on behalf of the consortium and as well invoiced individually to the respective partner.
Losnummer: 2
Bezeichnung des Loses: MTD studies for the Marine Fungi Consortium - compound 2
Losnummer: 3
Bezeichnung des Loses: MTD studies for the Marine Fungi Consortium - compound 3
Losnummer: 4
Bezeichnung des Loses: MTD studies for the Marine Fungi Consortium - compound 4
Losnummer: 5
Bezeichnung des Loses: MTD studies for the Marine Fungi Consortium - compound 5
Es werden Varianten akzeptiert ✅
Menge oder Umfang:
Maximal Tolerable Dose (MTD) studies of up to 5 compounds for the MARINE FUNGI Consortium.
Bezeichnung des von der EU finanzierten Projekts oder Programms:
Marine fungi
THEME [KBBE.2010.3.2-01] [Sustainable culture of marine microorganisms, algae and/or invertebrates for high added value products - Call: FP7-KBBE-2010-4]

Rechtliche, wirtschaftliche, finanzielle und technische Informationen
Auftragsausführung
Geforderte Kautionen und Garantien: no.
Sonstige besondere Bedingungen:
The consortium is expecting a combined quote for all 5 MTD studies on behalf of the MARINE FUNGI consortium. It should be directed to the following address:
Dr. Philip Gribbon
European ScreeningPort GmbH
Schnackenburgallee 114
22525 Hamburg
GERMANY
The orders for each of the 5 MTD studies will be placed individually by a specific partner of the MARINE FUNGI consortium on behalf of the consortium and as well invoiced individually to the respective partner. The MTD studies will be ordered in packages of 2 followed by 3 studies. The MARINE FUNGI consortium would prefer to place the orders for the MTD studies with the same provider as the additionally planned Xenograft studies. Please review the URS 'Xenograft studies for MARINE FUNGI' (separate document).
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The first closing date for receipt of applications will be 6.12.2013.
The intellectual property that may be generated in the course of this study, fully reverts to the MARINE FUNGI consortium.

Verfahren
Laufzeit der Rahmenvereinbarung in Monaten: 3
Sprachen
Sprache: Englisch 🗣️

Öffentlicher Auftraggeber
Identität
Andere Art des öffentlichen Auftraggebers: Other
Name des öffentlichen Auftraggebers: Marine Fungi Consortium at GEOMAR Helmholtz-Zentrum für Ozeanforschung Kiel
Postanschrift: Wischhofstr. 1-3
Postort: Kiel
Postleitzahl: 24148
Kontakt
Kontaktperson: European ScreeningPort GmbH - Marine fungi
Dr. Mira Grättinger
Internetadresse: www.screeningport.com 🌏
Adresse des Käuferprofils: https://www.marinefungi.eu 🌏

Referenz
Daten
Datum des Beginns: 2013-12-08 📅
Datum des Endes: 2014-03-07 📅
Quelle: OJS 2013/S 232-403021 (2013-11-27)
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